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Proteins/UNIPROT:A6NCL1

GMNC

Protein·UNIPROT:A6NCL1

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Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity)..

Function from UniProtKB (A6NCL1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

10 statements

10 statements · 3 reference databases · Subject: GMNC · Sources: gene ontology, Hetionet, Reactome

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GMNC covaries with ALDH16A1ProteinHetionet hetionet:covaries:126133-647309Inferred only
GMNC covaries with NLRP14ProteinHetionet hetionet:covaries:338323-647309Inferred only
GMNC covaries with RIF1ProteinHetionet hetionet:covaries:55183-647309Inferred only
GMNC covaries with ZNF445ProteinHetionet hetionet:covaries:353274-647309Inferred only
GMNC participates in Assembly of the 9+2 motile ciliaPathwayReactome R-HSA-9975924Inferred only
GMNC participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
GMNC participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
GMNC participates in Transcriptional regulation of multiciliogenesisPathwayReactome R-HSA-9945556Inferred only
GMNC regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology A6NCL1|GO:0045944Inferred only
GMNC regulates regulation of DNA-templated DNA replication initiationBiological processgene ontology A6NCL1|GO:0030174Inferred only

Other names

2 names

Resolves to: GMNC

Also called: GEMC1Geminin coiled-coil domain-containing protein 1

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