Proteins/UNIPROT:P51956

NEK3

ProteinUNIPROT:P51956

Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2..

Function from UniProtKB (P51956), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 3 reference databases · Subject: NEK3 · Sources: Hetionet, UniProt, WikiPathways

Order

NEK3 covaries with EPG5ProteinHetionet hetionet:covaries:4752-57724Inferred only
NEK3 covaries with FGFBP3ProteinHetionet hetionet:covaries:143282-4752Inferred only
NEK3 covaries with HEPN1ProteinHetionet hetionet:covaries:4752-641654Inferred only
NEK3 covaries with OAZ1ProteinHetionet hetionet:covaries:4752-4946Inferred only
BPGM interacts with NEK3ProteinHetionet hetionet:interacts:4752-669Inferred only
NEK3 interacts with CDCA8ProteinHetionet hetionet:interacts:4752-55143Inferred only
NEK3 interacts with NMNAT1ProteinHetionet hetionet:interacts:4752-64802Inferred only
NEK3 interacts with PRLRProteinHetionet hetionet:interacts:4752-5618Inferred only
NEK3 interacts with VAV1ProteinHetionet hetionet:interacts:4752-7409Inferred only
NEK3 interacts with VAV2ProteinHetionet hetionet:interacts:4752-7410Inferred only
NEK3 participates in Prolactin signalingPathwayWikiPathways WP2037Inferred only
NEK3 decreases the expression of ABL1ProteinHetionet hetionet:regulates:4752-25Inferred only

Show the remaining 5

NEK3 decreases the expression of BPHLProteinHetionet hetionet:regulates:4752-670Inferred only
NEK3 decreases the expression of PLEKHJ1ProteinHetionet hetionet:regulates:4752-55111Inferred only
NEK3 decreases the expression of SUZ12ProteinHetionet hetionet:regulates:4752-23512Inferred only
NEK3 decreases the expression of TM9SF3ProteinHetionet hetionet:regulates:4752-56889Inferred only
NEK3 requires the cofactor magnesium(2+)CompoundUniProt P51956Inferred only

Reactions

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

Other names

3 names

Resolves to: NEK3

Also called: HSPK 36Never in mitosis A-related kinase 3NimA-related protein kinase 3

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