Proteins/UNIPROT:Q9UHB4

NDOR1

ProteinUNIPROT:Q9UHB4

NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair. In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A..

Function from UniProtKB (Q9UHB4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 3 reference databases · Subject: NDOR1 · Sources: Hetionet, Reactome, UniProt

Order

NDOR1 covaries with IFT54ProteinHetionet hetionet:covaries:26146-27158Inferred only
NDOR1 interacts with CYCSProteinHetionet hetionet:interacts:27158-54205Inferred only
DLG4 interacts with NDOR1ProteinHetionet hetionet:interacts:1742-27158Inferred only
UBC interacts with NDOR1ProteinHetionet hetionet:interacts:27158-7316Inferred only
NDOR1 participates in Cytosolic iron-sulfur cluster assemblyPathwayReactome R-HSA-2564830Inferred only
NDOR1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
NDOR1 requires the cofactor FAD(3-)CompoundUniProt Q9UHB4Inferred only
NDOR1 requires the cofactor FMNCompoundUniProt Q9UHB4Inferred only

Reactions

1 reaction

2oxidized [2Fe-2S]-[protein]+NADPH(4-)2reduced [2Fe-2S]-[protein]+NADP(3-)+hydron
Catalysed by NDOR1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67716CC BY 4.0Reference data

Other names

3 names

Resolves to: NDOR1

Also called: NADPH-dependent FMN and FAD-containing oxidoreductaseNovel reductase 1NR1

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