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Proteins/UNIPROT:Q8IZF0
Voltage-sensing, pore-forming subunit of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents. The NALCN channelosome complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability. The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations. In addition to its role in regulating neuronal excitability, is required for normal respiratory rhythm, systemic osmoregulation by controlling the serum sodium concentration and in the regulation of the intestinal pace-making activity in the interstitial cells of Cajal (By similarity). The NALCN channelosome is also activated by neuropeptides such as neurotensin and substance P (SP) through a SRC family kinases-dependent pathway (By similarity). In addition, NALCN activity is enhanced/modulated by several GPCRs, such as CHRM3 (By similarity)..
Function from UniProtKB (Q8IZF0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
6 rows
2 reactions
Transported by SCN1A or SCN2A or SCN3A or SCN4A or SCN5A or SCN7A or SCN8A or SCN9A or SCN10A or SCN11A or HCN1 or HCN4 and 5 more alternatives
Reaction pageReversibleBalancedGO:0005615, GO:0005829
Human-GEM MAR01527CC BY 4.0Reference data
4 names
Resolves to: NALCN
Transported by ANO9 or HTR3E or TMEM150C or KCNK1 or KCNK3 or GRIN2D or GRID2 or KCNQ3 or KCNQ2 or GRIN3B or HCN1 or TRPA1 and 98 more alternatives
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:34963CC BY 4.0Reference data