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Proteins/UNIPROT:O14894
Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression..
Function from UniProtKB (O14894), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 statements
2 statements · 2 reference databases · Subject: TM4SF5 · Sources: gene ontology, Hetionet
2 names
Resolves to: TM4SF5