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Proteins/UNIPROT:Q9UIK4
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Regulates granulocytic motility by controlling cell spreading and polarization..
Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
Function from UniProtKB (Q9UIK4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
19 statements
19 statements · 5 reference databases · Subject: DAPK2 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
2 reactions
3 names
Resolves to: DAPK2
Rhea RHEA:17989CC BY 4.0Reference data