Proteins/UNIPROT:Q9NXL9

MCM9

ProteinUNIPROT:Q9NXL9

Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Plays a key role during gametogenesis, probably by regulating HR (By similarity)..

Function from UniProtKB (Q9NXL9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

46,XX ovarian dysgenesis-short stature syndrome has a germline basis in MCM9DiseaseGenCC HGNC:21484|MONDO:0014520Inferred only
hereditary neoplastic syndrome has a germline basis in MCM9DiseaseGenCC HGNC:21484|MONDO:0015356Inferred only
MCM9-related gametogenic failure has a germline basis in MCM9DiseaseGenCC HGNC:21484|MONDO:1060226Inferred only
premature ovarian failure 10 has a germline basis in MCM9DiseaseGenCC HGNC:21484|MONDO:0044776Inferred only

Statements

7 statements

7 statements · 3 reference databases · Subject: MCM9 · Sources: Hetionet, UniProt, WikiPathways

Order

MCM9 covaries with MDC1ProteinHetionet hetionet:covaries:254394-9656Inferred only
MCM9 covaries with PYDC1ProteinHetionet hetionet:covaries:254394-260434Inferred only
MCM9 participates in Ciliary landscapePathwayWikiPathways WP4352Inferred only
MCM9 participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
HDAC2 decreases the expression of MCM9ProteinHetionet hetionet:regulates:3066-254394Inferred only
MYCBP decreases the expression of MCM9ProteinHetionet hetionet:regulates:26292-254394Inferred only
MCM9 requires the cofactor Zn(2+)CompoundUniProt Q9NXL9Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

6 names

Resolves to: MCM9

Also called: C6orf61DNA 3'-5' helicase MCM9hMCM9MCMDC1Mini-chromosome maintenance deficient domain-containing protein 1Minichromosome maintenance 9

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