premature ovarian failure 10
MONDO:0044776Mondo
Findings
No curated finding names premature ovarian failure 10 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Autosomal recessive inheritance
HPO, annotations 2026-09-02
Features
5 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Elevated circulating follicle stimulating hormone levelHPOHP:0008232
- Hypoplasia of the ovaryHPOHP:0008724
- Female
- HypothyroidismHPOHP:0000821
- Premature ovarian insufficiencyHPOHP:0008209
- Primary amenorrheaHPOHP:0000786
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- MCM9HGNC:21484
- Definitive · Ambry Genetics · Autosomal recessive · 2024
- Limited · Ambry Genetics · Autosomal dominant · 2024
- MCM8HGNC:16147
- Strong · Ambry Genetics · Autosomal recessive · 2024
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal recessive · 2020
- Strong · PanelApp Australia · Autosomal recessive · 2025
- Moderate · Ambry Genetics · Autosomal recessive · 2020
- Limited · Ambry Genetics · Autosomal dominant · 2024
Where it sits
- A kind of