Proteins/UNIPROT:Q8WXC3

PYDC1

ProteinUNIPROT:Q8WXC3

Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS..

Function from UniProtKB (Q8WXC3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

11 statements

11 statements · 2 reference databases · Subject: PYDC1 · Sources: gene ontology, Hetionet

Order

CCDC141 covaries with PYDC1ProteinHetionet hetionet:covaries:260434-285025Inferred only
FAM217A covaries with PYDC1ProteinHetionet hetionet:covaries:222826-260434Inferred only
MCM9 covaries with PYDC1ProteinHetionet hetionet:covaries:254394-260434Inferred only
PARP9 covaries with PYDC1ProteinHetionet hetionet:covaries:260434-83666Inferred only
PYDC1 covaries with TCN1ProteinHetionet hetionet:covaries:260434-6947Inferred only
TRAF3IP2 covaries with PYDC1ProteinHetionet hetionet:covaries:10758-260434Inferred only
PYCARD interacts with PYDC1ProteinHetionet hetionet:interacts:260434-29108Inferred only
PYDC1 regulates negative regulation of canonical NF-kappaB signal transductionBiological processgene ontology Q8WXC3|GO:0043124Inferred only
PYDC1 regulates negative regulation of interleukin-1-mediated signaling pathwayBiological processgene ontology Q8WXC3|GO:2000660Inferred only
PYDC1 regulates negative regulation of tumor necrosis factor-mediated signaling pathwayBiological processgene ontology Q8WXC3|GO:0010804Inferred only
PYDC1 regulates positive regulation of interleukin-1 beta productionBiological processgene ontology Q8WXC3|GO:0032731Inferred only

Other names

8 names

Resolves to: PYDC1

Also called: ASC2ASCIcellular POP1cPOP1PAAD-only protein 1POP1PYC1Pyrin-only protein 1

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