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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P33032

MC5R

Protein·UNIPROT:P33032

Open in the graph

G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway. Also activates ERK1/2 via a PI3K-dependent signaling mechanism. Order of potency of natural melanocortins in receptor activation is alpha-MSH > ACTH > beta-MSH > gamma-MSH. Plays a key role in immune response, and is essential for temperature regulation and exocrine gland function (By similarity)..

Function from UniProtKB (P33032), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

25 statements

25 statements · 5 reference databases · Subject: MC5R · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

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MC5R covaries with KRABD3ProteinHetionet hetionet:covaries:4161-84626Inferred only
MC5R covaries with LDLRAD4ProteinHetionet hetionet:covaries:4161-753Inferred only
MC5R covaries with OR51B6ProteinHetionet hetionet:covaries:390058-4161Inferred only
MC5R covaries with RPS16ProteinHetionet hetionet:covaries:4161-6217Inferred only
AGRP interacts with MC5RProteinHetionet hetionet:interacts:181-4161Inferred only
ASIP interacts with MC5RProteinHetionet hetionet:interacts:4161-434Inferred only
MC5R interacts with MRAPProteinHetionet hetionet:interacts:4161-56246Inferred only
MC5R interacts with MRAP2ProteinHetionet hetionet:interacts:112609-4161Inferred only
MC5R interacts with POMCProteinHetionet hetionet:interacts:4161-5443Inferred only
MC5R participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
MC5R participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
MC5R participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only

Show the remaining 13

MC5R participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
MC5R participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
MC5R participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
MC5R participates in MITF-M-regulated melanocyte developmentPathwayReactome R-HSA-9730414Inferred only
MC5R participates in Peptide GPCRsPathwayWikiPathways WP24Inferred only
MC5R participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
MC5R participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
MC5R participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
MC5R participates in Transcriptional and post-translational regulation of MITF-M expression and activityPathwayReactome R-HSA-9856649Inferred only
MC5R regulates negative regulation of immune responseBiological processgene ontology P33032|GO:0050777Inferred only
MC5R regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology P33032|GO:0070374Inferred only
MC5R regulates positive regulation of exocytosisBiological processgene ontology P33032|GO:0045921Inferred only
MC5R requires the cofactor Ca(2+)CompoundUniProt P33032Inferred only

Other names

2 names

Resolves to: MC5R

Also called: MC-2MC5-R

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