Proteins/UNIPROT:O00253

AGRP

ProteinUNIPROT:O00253

Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptors MC3R and MC4R by precluding agonist-induced signaling, thereby inhibiting cAMP production within the hypothalamus and adrenal gland. Involved in the control of feeding behavior via the central melanocortin system. Has very low activity towards MC5R. Also promotes endocytosis of MC3R and MC4R in an arrestin-dependent mechanism..

Function from UniProtKB (O00253), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 4 reference databases · Subject: AGRP · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

OR2V2 covaries with AGRPProteinHetionet hetionet:covaries:181-285659Inferred only
AGRP interacts with GHRLProteinHetionet hetionet:interacts:181-51738Inferred only
AGRP interacts with MC3RProteinHetionet hetionet:interacts:181-4159Inferred only
AGRP interacts with MC4RProteinHetionet hetionet:interacts:181-4160Inferred only
AGRP interacts with MC5RProteinHetionet hetionet:interacts:181-4161Inferred only
AGRP participates in 6q16 copy number variationPathwayWikiPathways WP5400Inferred only
AGRP participates in Circadian rhythm genesPathwayWikiPathways WP3594Inferred only
AGRP participates in FOXO-mediated transcriptionPathwayReactome R-HSA-9614085Inferred only
AGRP participates in FOXO-mediated transcription of oxidative stress, metabolic and neuronal genesPathwayReactome R-HSA-9615017Inferred only
AGRP participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
AGRP participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
AGRP participates in Hunger and satietyPathwayWikiPathways WP5445Inferred only

Show the remaining 7

AGRP participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
AGRP participates in Thyroid hormones production and peripheral downstream signaling effectsPathwayWikiPathways WP4746Inferred only
AGRP regulates negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayBiological processgene ontology O00253|GO:0106072Inferred only
AGRP regulates positive regulation of appetiteBiological processgene ontology O00253|GO:0032100Inferred only
AGRP regulates positive regulation of feeding behaviorBiological processgene ontology O00253|GO:2000253Inferred only
AGRP regulates regulation of appetiteBiological processgene ontology O00253|GO:0032098Inferred only
AGRP regulates regulation of feeding behaviorBiological processgene ontology O00253|GO:0060259Inferred only

Other names

3 names

Resolves to: AGRP

Also called: Agouti-related proteinAGRTART

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