Proteins/UNIPROT:P35556

FBN2

ProteinUNIPROT:P35556

[Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively..

[Placensin]: Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels (By similarity)..

Function from UniProtKB (P35556), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

congenital contractural arachnodactyly has a germline basis in FBN2DiseaseGenCC HGNC:3604|MONDO:0007363Inferred only

Statements

24 statements

24 statements · 4 reference databases · Subject: FBN2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

FBN2 covaries with PPM1JProteinHetionet hetionet:covaries:2201-333926Inferred only
ECM1 interacts with FBN2ProteinHetionet hetionet:interacts:1893-2201Inferred only
ELN interacts with FBN2ProteinHetionet hetionet:interacts:2006-2201Inferred only
FBN2 interacts with FBXO6ProteinHetionet hetionet:interacts:2201-26270Inferred only
FBN2 interacts with GFI1ProteinHetionet hetionet:interacts:2201-2672Inferred only
FBN2 interacts with LTBP1ProteinHetionet hetionet:interacts:2201-4052Inferred only
FBN2 interacts with MATN2ProteinHetionet hetionet:interacts:2201-4147Inferred only
FBN2 interacts with MFAP2ProteinHetionet hetionet:interacts:2201-4237Inferred only
FBN2 interacts with MFAP5ProteinHetionet hetionet:interacts:2201-8076Inferred only
FBN2 interacts with SMAD2ProteinHetionet hetionet:interacts:2201-4087Inferred only
FBN2 interacts with UBCProteinHetionet hetionet:interacts:2201-7316Inferred only
FBN2 interacts with ZNF8ProteinHetionet hetionet:interacts:2201-7554Inferred only

Show the remaining 12

FBN2 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
FBN2 participates in Elastic fibre formationPathwayReactome R-HSA-1566948Inferred only
FBN2 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
FBN2 participates in Hypothesized pathways in pathogenesis of cardiovascular diseasePathwayWikiPathways WP3668Inferred only
FBN2 participates in Molecules associated with elastic fibresPathwayReactome R-HSA-2129379Inferred only
FBN2 regulates negative regulation of transforming growth factor beta receptor signaling pathwayBiological processgene ontology P35556|GO:0030512Inferred only
FBN2 regulates positive regulation of bone mineralizationBiological processgene ontology P35556|GO:0030501Inferred only
FBN2 regulates positive regulation of osteoblast differentiationBiological processgene ontology P35556|GO:0045669Inferred only
CPE increases the expression of FBN2ProteinHetionet hetionet:regulates:1363-2201Inferred only
NQO1 increases the expression of FBN2ProteinHetionet hetionet:regulates:1728-2201Inferred only
PPARA decreases the expression of FBN2ProteinHetionet hetionet:regulates:5465-2201Inferred only
UCHL1 decreases the expression of FBN2ProteinHetionet hetionet:regulates:7345-2201Inferred only

Other names

1 name

Resolves to: FBN2

Also called: Fibrillin-2 [Cleaved into: Placensin]

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