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Proteins/UNIPROT:Q8NC69
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation..
Function from UniProtKB (Q8NC69), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 3 reference databases · Subject: KCTD6 · Sources: gene ontology, Hetionet, Reactome
2 names
Resolves to: KCTD6