Proteins/UNIPROT:Q6PIL6

KCNIP4

ProteinUNIPROT:Q6PIL6

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane..

Function from UniProtKB (Q6PIL6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 3 reference databases · Subject: KCNIP4 · Sources: gene ontology, Hetionet, Reactome

Order

KCNIP4 covaries with FSTL3ProteinHetionet hetionet:covaries:10272-80333Inferred only
KCNIP4 covaries with MON1AProteinHetionet hetionet:covaries:80333-84315Inferred only
KCNIP4 covaries with RNF26ProteinHetionet hetionet:covaries:79102-80333Inferred only
SHISA9 covaries with KCNIP4ProteinHetionet hetionet:covaries:729993-80333Inferred only
APP interacts with KCNIP4ProteinHetionet hetionet:interacts:351-80333Inferred only
KCND2 interacts with KCNIP4ProteinHetionet hetionet:interacts:3751-80333Inferred only
KCNIP2 interacts with KCNIP4ProteinHetionet hetionet:interacts:30819-80333Inferred only
PSEN2 interacts with KCNIP4ProteinHetionet hetionet:interacts:5664-80333Inferred only
KCNIP4 participates in Cardiac conductionPathwayReactome R-HSA-5576891Inferred only
KCNIP4 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
KCNIP4 participates in Phase 1 - inactivation of fast Na+ channelsPathwayReactome R-HSA-5576894Inferred only
KCNIP4 regulates regulation of potassium ion transmembrane transportBiological processgene ontology Q6PIL6|GO:1901379Inferred only

Show the remaining 1

KCNIP4 regulates regulation of signal transductionBiological processgene ontology Q6PIL6|GO:0009966Inferred only

Other names

5 names

Resolves to: KCNIP4

Also called: A-type potassium channel modulatory protein 4CALPCalsenilin-like proteinKCHIP4Potassium channel-interacting protein 4

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