Pathway
Phase 1 - inactivation of fast Na+ channels
Phase 1 of the cardiac action potential is the inactivation of the fast Na+ channels. The transient net outward current causing the small downward deflection (the "notch" of the action potetial) is due to the movement of K+ and Cl- ions. In pacemaker cells, this phase is due to rapid K+ efflux and closure of L-type Ca2+ channels.
REACT:R-HSA-5576894Reactome
What the reference databases state
Statements
7 statements
7 statements · 1 reference database · Subject: Phase 1 - inactivation of fast Na+ channels · Sources: Reactome
- KCND1 participates in Phase 1 - inactivation of fast Na+ channelsProteinReactome R-HSA-5576894Inferred only
- KCND2 participates in Phase 1 - inactivation of fast Na+ channelsProteinReactome R-HSA-5576894Inferred only
- KCND3 participates in Phase 1 - inactivation of fast Na+ channelsProteinReactome R-HSA-5576894Inferred only
- KCNIP1 participates in Phase 1 - inactivation of fast Na+ channelsProteinReactome R-HSA-5576894Inferred only
- KCNIP2 participates in Phase 1 - inactivation of fast Na+ channelsProteinReactome R-HSA-5576894Inferred only
- KCNIP3 participates in Phase 1 - inactivation of fast Na+ channelsProteinReactome R-HSA-5576894Inferred only
- KCNIP4 participates in Phase 1 - inactivation of fast Na+ channelsProteinReactome R-HSA-5576894Inferred only