Proteins/UNIPROT:P10997

IAPP

ProteinUNIPROT:P10997

Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis. Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes (By similarity). Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity)..

Function from UniProtKB (P10997), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 3 reference databases · Subject: IAPP · Sources: gene ontology, Hetionet, Reactome

Order

OR13C5 covaries with IAPPProteinHetionet hetionet:covaries:138799-3375Inferred only
IAPP participates in Amyloid fiber formationPathwayReactome R-HSA-977225Inferred only
IAPP participates in Calcitonin-like ligand receptorsPathwayReactome R-HSA-419812Inferred only
IAPP participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
IAPP participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
IAPP participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
IAPP participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
IAPP participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
IAPP participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
IAPP participates in Regulation of beta-cell developmentPathwayReactome R-HSA-186712Inferred only
IAPP participates in Regulation of gene expression in beta cellsPathwayReactome R-HSA-210745Inferred only
IAPP participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Show the remaining 7

IAPP participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
IAPP regulates negative regulation of amyloid fibril formationBiological processgene ontology P10997|GO:1905907Inferred only
IAPP regulates negative regulation of protein-containing complex assemblyBiological processgene ontology P10997|GO:0031333Inferred only
IAPP regulates positive regulation of apoptotic processBiological processgene ontology P10997|GO:0043065Inferred only
IAPP regulates positive regulation of calcium-mediated signalingBiological processgene ontology P10997|GO:0050850Inferred only
IAPP regulates positive regulation of cAMP/PKA signal transductionBiological processgene ontology P10997|GO:0141163Inferred only
IAPP regulates positive regulation of MAPK cascadeBiological processgene ontology P10997|GO:0043410Inferred only

Other names

4 names

Resolves to: IAPP

Also called: AmylinDAPDiabetes-associated peptideInsulinoma amyloid peptide

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