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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9H9Y4

GPN2

Protein·UNIPROT:Q9H9Y4

Open in the graph

Small GTPase involved in the correct assembly of RNA polymerase RNA polymerase II and III (RNAPII and RNAPIII) complexes, ensuring their proper nuclear import..

Function from UniProtKB (Q9H9Y4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

complex neurodevelopmental disorder has a germline basis in GPN2DiseaseGenCC HGNC:25513|MONDO:0100038Inferred only

Statements

7 statements

7 statements · 1 reference database · Subject: GPN2 · Sources: Hetionet

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ZNF354B covaries with GPN2ProteinHetionet hetionet:covaries:117608-54707Inferred only
APP interacts with GPN2ProteinHetionet hetionet:interacts:351-54707Inferred only
DNAJB1 increases the expression of GPN2ProteinHetionet hetionet:regulates:3337-54707Inferred only
EGR1 increases the expression of GPN2ProteinHetionet hetionet:regulates:1958-54707Inferred only
HDGFL3 increases the expression of GPN2ProteinHetionet hetionet:regulates:50810-54707Inferred only
KMT2A increases the expression of GPN2ProteinHetionet hetionet:regulates:4297-54707Inferred only
KTN1 increases the expression of GPN2ProteinHetionet hetionet:regulates:3895-54707Inferred only

Reactions

1 reaction

GTP+waterGDP+hydrogenphosphate+hydron
Catalysed by IRGM or RAB19 or TUBAL3 or GTPBP1 or RAB27B or RHOD or DNM1L or MRAS or RAB29 or OPA1 or EIF5B or ENTPD3 and 183 more alternatives
Reaction page

Other names

2 names

Resolves to: GPN2

Also called: ATP-binding domain 1 family member BATPBD1B

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Rhea RHEA:19669CC BY 4.0Reference data