Proteins/UNIPROT:Q9H6L5

RETREG1

ProteinUNIPROT:Q9H6L5

Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Active under basal conditions. Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons..

(Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein. This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection..

Function from UniProtKB (Q9H6L5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

hereditary sensory and autonomic neuropathy has a germline basis in RETREG1DiseaseGenCC HGNC:25964|MONDO:0015364Inferred only
hereditary sensory and autonomic neuropathy type 2 has a germline basis in RETREG1DiseaseGenCC HGNC:25964|MONDO:0019941Inferred only
neuropathy, hereditary sensory and autonomic, type 2B has a germline basis in RETREG1DiseaseGenCC HGNC:25964|MONDO:0013142Inferred only

Statements

20 statements

20 statements · 3 reference databases · Subject: RETREG1 · Sources: gene ontology, Hetionet, Reactome

Order

RETREG1 covaries with C1orf74ProteinHetionet hetionet:covaries:148304-54463Inferred only
RETREG1 covaries with DCAF16ProteinHetionet hetionet:covaries:54463-54876Inferred only
RETREG1 covaries with FAM43BProteinHetionet hetionet:covaries:163933-54463Inferred only
RETREG1 covaries with FLRT1ProteinHetionet hetionet:covaries:23769-54463Inferred only
RETREG1 covaries with KRTAP10-4ProteinHetionet hetionet:covaries:386672-54463Inferred only
RASGRP2 covaries with RETREG1ProteinHetionet hetionet:covaries:10235-54463Inferred only
RETREG1 covaries with SLIT1ProteinHetionet hetionet:covaries:54463-6585Inferred only
RETREG1 covaries with UNC5CProteinHetionet hetionet:covaries:54463-8633Inferred only
RETREG1 covaries with ZNF699ProteinHetionet hetionet:covaries:374879-54463Inferred only
APP interacts with RETREG1ProteinHetionet hetionet:interacts:351-54463Inferred only
SNAPIN interacts with RETREG1ProteinHetionet hetionet:interacts:23557-54463Inferred only
RETREG1 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only

Show the remaining 8

RETREG1 participates in Dengue virus modulates apoptosisPathwayReactome R-HSA-9920951Inferred only
RETREG1 participates in Dengue Virus-Host InteractionsPathwayReactome R-HSA-9918481Inferred only
RETREG1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
RETREG1 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
RETREG1 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
RETREG1 regulates negative regulation of neuron apoptotic processBiological processgene ontology Q9H6L5|GO:0043524Inferred only
HDAC2 increases the expression of RETREG1ProteinHetionet hetionet:regulates:3066-54463Inferred only
RYK increases the expression of RETREG1ProteinHetionet hetionet:regulates:6259-54463Inferred only

Other names

4 names

Resolves to: RETREG1

Also called: FAM134BJK1Reticulophagy receptor 1Reticulophagy regulator 1

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