Proteins/UNIPROT:Q5U623

ATF7IP2

ProteinUNIPROT:Q5U623

Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable)..

Function from UniProtKB (Q5U623), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 2 reference databases · Subject: ATF7IP2 · Sources: gene ontology, Hetionet

Order

AKAP9 covaries with ATF7IP2ProteinHetionet hetionet:covaries:10142-80063Inferred only
ATF7IP2 covaries with ANKRD42ProteinHetionet hetionet:covaries:338699-80063Inferred only
CEP162 covaries with ATF7IP2ProteinHetionet hetionet:covaries:22832-80063Inferred only
CNTROB covaries with ATF7IP2ProteinHetionet hetionet:covaries:116840-80063Inferred only
CUL7 covaries with ATF7IP2ProteinHetionet hetionet:covaries:80063-9820Inferred only
FKTN covaries with ATF7IP2ProteinHetionet hetionet:covaries:2218-80063Inferred only
IQCB1 covaries with ATF7IP2ProteinHetionet hetionet:covaries:80063-9657Inferred only
ATF7IP2 covaries with LEFTY2ProteinHetionet hetionet:covaries:7044-80063Inferred only
ATF7IP2 covaries with MPLProteinHetionet hetionet:covaries:4352-80063Inferred only
RIF1 covaries with ATF7IP2ProteinHetionet hetionet:covaries:55183-80063Inferred only
ATF7IP2 covaries with TP53BP1ProteinHetionet hetionet:covaries:7158-80063Inferred only
TRIM59 covaries with ATF7IP2ProteinHetionet hetionet:covaries:286827-80063Inferred only

Show the remaining 5

ATF7IP2 covaries with TWNKProteinHetionet hetionet:covaries:56652-80063Inferred only
MBD1 interacts with ATF7IP2ProteinHetionet hetionet:interacts:4152-80063Inferred only
SETDB1 interacts with ATF7IP2ProteinHetionet hetionet:interacts:80063-9869Inferred only
SP1 interacts with ATF7IP2ProteinHetionet hetionet:interacts:6667-80063Inferred only
ATF7IP2 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q5U623|GO:0006355Inferred only

Other names

3 names

Resolves to: ATF7IP2

Also called: ATF7-interacting protein 2MBD1-containing chromatin-associated factor 2MCAF2

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