Pathway
Deadenylation of mRNA
Deadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 complex. In the second step the poly(A) tail is further shortened to 10-15 residues by either the CCR4-NOT complex or by the PARN exoribonuclease. How a particular mRNA is targeted to CCR4-NOT or PARN is unknown.
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A number of other deadenylase enzymes can be identified in genomic searches. One particularly interesting one is nocturin, a protein that is related to the CCR-1 deadenylase and plays a role in circadian rhythms.
There is also evidence for networking between deadenylation and other aspects of gene expression. CCR4-NOT, for example, is known to be a transcription factor. PARN is part of a complex that regulates poly(A) tail length and hence translation in developing oocytes.
What the reference databases state
Statements
25 statements
25 statements · 1 reference database · Subject: Deadenylation of mRNA · Sources: Reactome
- CNOT1 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- CNOT10 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- CNOT11 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- CNOT12 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- CNOT2 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- CNOT3 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- CNOT4 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- CNOT6 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- CNOT6L participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- CNOT7 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- CNOT8 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- CNOT9 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
Show the remaining 13
- EIF4A1 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- EIF4A2 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- EIF4A3 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- EIF4B participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- EIF4E participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- EIF4G1 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- PABPC1 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- PAIP1 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- PAN2 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- PAN3 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- PARN participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- TUT4 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only
- TUT7 participates in Deadenylation of mRNAProteinReactome R-HSA-429947Inferred only