Proteins/UNIPROT:O43379

WDR62

ProteinUNIPROT:O43379

Required for cerebral cortical development. Plays a role in neuronal proliferation and migration. Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication..

Function from UniProtKB (O43379), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

autosomal recessive primary microcephaly has a germline basis in WDR62DiseaseGenCC HGNC:24502|MONDO:0016660Inferred only
microcephaly 2, primary, autosomal recessive, with or without cortical malformations has a germline basis in WDR62DiseaseGenCC HGNC:24502|MONDO:0011435Inferred only

Statements

17 statements

17 statements · 3 reference databases · Subject: WDR62 · Sources: gene ontology, Hetionet, WikiPathways

Order

WDR62 covaries with DPEP3ProteinHetionet hetionet:covaries:284403-64180Inferred only
WDR62 covaries with GALNT8ProteinHetionet hetionet:covaries:26290-284403Inferred only
MYL5 covaries with WDR62ProteinHetionet hetionet:covaries:284403-4636Inferred only
ZSCAN12 covaries with WDR62ProteinHetionet hetionet:covaries:284403-9753Inferred only
LRIF1 interacts with WDR62ProteinHetionet hetionet:interacts:284403-55791Inferred only
MAP2K7 interacts with WDR62ProteinHetionet hetionet:interacts:284403-5609Inferred only
MAPK8 interacts with WDR62ProteinHetionet hetionet:interacts:284403-5599Inferred only
MAPK9 interacts with WDR62ProteinHetionet hetionet:interacts:284403-5601Inferred only
RALY interacts with WDR62ProteinHetionet hetionet:interacts:22913-284403Inferred only
RIF1 interacts with WDR62ProteinHetionet hetionet:interacts:284403-55183Inferred only
TBP interacts with WDR62ProteinHetionet hetionet:interacts:284403-6908Inferred only
UBC interacts with WDR62ProteinHetionet hetionet:interacts:284403-7316Inferred only

Show the remaining 5

WDR62 participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
WDR62 regulates positive regulation of neuroblast proliferationBiological processgene ontology O43379|GO:0002052Inferred only
WDR62 regulates positive regulation of neuron migrationBiological processgene ontology O43379|GO:2001224Inferred only
WDR62 regulates regulation of centrosome cycleBiological processgene ontology O43379|GO:0046605Inferred only
WDR62 regulates regulation of neuron differentiationBiological processgene ontology O43379|GO:0045664Inferred only

Other names

2 names

Resolves to: WDR62

Also called: C19orf14WD repeat-containing protein 62

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