Proteins/UNIPROT:Q9BUQ8

DDX23

ProteinUNIPROT:Q9BUQ8

Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA..

Function from UniProtKB (Q9BUQ8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

complex neurodevelopmental disorder has a germline basis in DDX23DiseaseGenCC HGNC:17347|MONDO:0100038Inferred only
neurodevelopmental disorder has a germline basis in DDX23DiseaseGenCC HGNC:17347|MONDO:0700092Inferred only

Statements

26 statements

26 statements · 2 reference databases · Subject: DDX23 · Sources: Hetionet, Reactome

Order

DDX23 covaries with KCNIP2ProteinHetionet hetionet:covaries:30819-9416Inferred only
NUDCD2 covaries with DDX23ProteinHetionet hetionet:covaries:134492-9416Inferred only
WNT7B covaries with DDX23ProteinHetionet hetionet:covaries:7477-9416Inferred only
DDX23 interacts with MEPCEProteinHetionet hetionet:interacts:56257-9416Inferred only
DDX23 interacts with PAXIP1ProteinHetionet hetionet:interacts:22976-9416Inferred only
DDX23 interacts with SIRT7ProteinHetionet hetionet:interacts:51547-9416Inferred only
SNRNP40 interacts with DDX23ProteinHetionet hetionet:interacts:9410-9416Inferred only
SUMO1 interacts with DDX23ProteinHetionet hetionet:interacts:7341-9416Inferred only
SUMO2 interacts with DDX23ProteinHetionet hetionet:interacts:6613-9416Inferred only
TERF1 interacts with DDX23ProteinHetionet hetionet:interacts:7013-9416Inferred only
DDX23 interacts with TERF2IPProteinHetionet hetionet:interacts:54386-9416Inferred only
UBC interacts with DDX23ProteinHetionet hetionet:interacts:7316-9416Inferred only

Show the remaining 14

DDX23 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
DDX23 participates in Dengue Virus-Host InteractionsPathwayReactome R-HSA-9918481Inferred only
DDX23 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
DDX23 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
DDX23 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
DDX23 participates in mRNA SplicingPathwayReactome R-HSA-72172Inferred only
DDX23 participates in mRNA Splicing - Major PathwayPathwayReactome R-HSA-72163Inferred only
DDX23 participates in mRNA Splicing - Minor PathwayPathwayReactome R-HSA-72165Inferred only
DDX23 participates in Processing of Capped Intron-Containing Pre-mRNAPathwayReactome R-HSA-72203Inferred only
DDX23 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
AURKA decreases the expression of DDX23ProteinHetionet hetionet:regulates:6790-9416Inferred only
GTF2E2 decreases the expression of DDX23ProteinHetionet hetionet:regulates:2961-9416Inferred only
RAD9A decreases the expression of DDX23ProteinHetionet hetionet:regulates:5883-9416Inferred only
SMARCB1 decreases the expression of DDX23ProteinHetionet hetionet:regulates:6598-9416Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

4 names

Resolves to: DDX23

Also called: 100 kDa U5 snRNP-specific proteinDEAD box protein 23PRP28 homologU5-100kD

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