Loading the page.
Proteins/UNIPROT:Q8N118
A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)..
Function from UniProtKB (Q8N118), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
9 statements
9 statements · 5 reference databases · Subject: CYP4X1 · Sources: Hetionet, Human-GEM, Rhea, UniProt, WikiPathways
4 reactions
1 name
Resolves to: CYP4X1
Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol
Human-GEM MAR00954CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate+FADH2+dioxygen14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+FAD+water
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 15 more alternatives
Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol
Human-GEM MAR00955CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate+FADH2+dioxygen14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+FAD+water
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 15 more alternatives
Reaction pageLeft to rightBalancedEC 1.14.14.1endoplasmic reticulum
Human-GEM MAR00956CC BY 4.0Reference data
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:136991+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP3A4 or CYP2D6 or CYP2B6 or CYP4X1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:53148CC BY 4.0Reference data