Proteins/UNIPROT:O76071

CIAO1

ProteinUNIPROT:O76071

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation..

Function from UniProtKB (O76071), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 4 reference databases · Subject: CIAO1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CIAO1 covaries with MIB2ProteinHetionet hetionet:covaries:142678-9391Inferred only
APP interacts with CIAO1ProteinHetionet hetionet:interacts:351-9391Inferred only
CIAO1 interacts with CCDC7ProteinHetionet hetionet:interacts:79741-9391Inferred only
CIAO1 interacts with CIAO2AProteinHetionet hetionet:interacts:84191-9391Inferred only
CIAO1 interacts with CIAO2BProteinHetionet hetionet:interacts:51647-9391Inferred only
DRC4 interacts with CIAO1ProteinHetionet hetionet:interacts:2622-9391Inferred only
CIAO1 interacts with GOLM1ProteinHetionet hetionet:interacts:51280-9391Inferred only
CIAO1 interacts with MMS19ProteinHetionet hetionet:interacts:64210-9391Inferred only
SRPK1 interacts with CIAO1ProteinHetionet hetionet:interacts:6732-9391Inferred only
UBC interacts with CIAO1ProteinHetionet hetionet:interacts:7316-9391Inferred only
CIAO1 interacts with WDR5ProteinHetionet hetionet:interacts:11091-9391Inferred only
WT1 interacts with CIAO1ProteinHetionet hetionet:interacts:7490-9391Inferred only

Show the remaining 4

CIAO1 participates in 2q11 2 copy number variation syndromePathwayWikiPathways WP5221Inferred only
CIAO1 participates in Cytosolic iron-sulfur cluster assemblyPathwayReactome R-HSA-2564830Inferred only
CIAO1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CIAO1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology O76071|GO:0006357Inferred only

Other names

4 names

Resolves to: CIAO1

Also called: CIA1Probable cytosolic iron-sulfur protein assembly protein CIAO1WD repeat-containing protein 39WDR39

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