Proteins/UNIPROT:P51679

CCR4

ProteinUNIPROT:P51679

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival..

Function from UniProtKB (P51679), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

21 statements

21 statements · 4 reference databases · Subject: CCR4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CCR4 interacts with CCL17ProteinHetionet hetionet:interacts:1233-6361Inferred only
CCR4 interacts with CCL22ProteinHetionet hetionet:interacts:1233-6367Inferred only
CCR4 interacts with CCL3ProteinHetionet hetionet:interacts:1233-6348Inferred only
CCR4 interacts with CCL5ProteinHetionet hetionet:interacts:1233-6352Inferred only
CCR4 interacts with CXCL12ProteinHetionet hetionet:interacts:1233-6387Inferred only
GRK2 interacts with CCR4ProteinHetionet hetionet:interacts:1233-156Inferred only
GRK3 interacts with CCR4ProteinHetionet hetionet:interacts:1233-157Inferred only
CCR4 participates in Chemokine receptors bind chemokinesPathwayReactome R-HSA-380108Inferred only
CCR4 participates in Chemokine signalingPathwayWikiPathways WP3929Inferred only
CCR4 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
CCR4 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
CCR4 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only

Show the remaining 9

CCR4 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
CCR4 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
CCR4 participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
CCR4 participates in Peptide GPCRsPathwayWikiPathways WP24Inferred only
CCR4 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
CCR4 participates in Selective expression of chemokine receptors during T cell polarizationPathwayWikiPathways WP4494Inferred only
CCR4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CCR4 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CCR4 regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology P51679|GO:0007204Inferred only

Other names

6 names

Resolves to: CCR4

Also called: C-C CKR-4CC-CKR-4CCR-4CD antigen CD194CMKBR4K5-5

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