Proteins/UNIPROT:Q6NS38

ALKBH2

ProteinUNIPROT:Q6NS38DNA oxidative demethylase ALKBH2

Dioxygenase that repairs alkylated nucleic acid bases by direct reversal oxidative dealkylation. Can process both double-stranded (ds) and single-stranded (ss) DNA substrates, with a strong preference for dsDNA. Uses molecular oxygen, 2-oxoglutarate and iron as cofactors to oxidize the alkyl groups that are subsequently released as aldehydes, regenerating the undamaged bases. Probes the base pair stability, locates a weakened base pair and flips the damaged base to accommodate the lesion in its active site for efficient catalysis. Repairs monoalkylated bases, specifically N1-methyladenine and N3-methylcytosine, as well as higher order alkyl adducts such as bases modified with exocyclic bridged adducts known as etheno adducts including 1,N6-ethenoadenine, 3,N4-ethenocytosine and 1,N2-ethenoguanine. Acts as a gatekeeper of genomic integrity under alkylation stress. Efficiently repairs alkylated lesions in ribosomal DNA (rDNA). These lesions can cause ss- and dsDNA strand breaks that severely impair rDNA transcription. In a response mechanism to DNA damage, associates with PCNA at replication forks to repair alkylated adducts prior to replication..

Function from UniProtKB (Q6NS38), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 4 reference databases · Subject: ALKBH2 · Sources: Hetionet, Reactome, UniProt, WikiPathways

Order

UBC interacts with ALKBH2ProteinHetionet hetionet:interacts:121642-7316Inferred only
ALKBH2 participates in ALKBH2 mediated reversal of alkylation damagePathwayReactome R-HSA-112122Inferred only
ALKBH2 participates in Direct reversal repairPathwayWikiPathways WP4931Inferred only
ALKBH2 participates in DNA Damage ReversalPathwayReactome R-HSA-73942Inferred only
ALKBH2 participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
ALKBH2 participates in Reversal of alkylation damage by DNA dioxygenasesPathwayReactome R-HSA-73943Inferred only
ALKBH2 requires the cofactor iron(2+)CompoundUniProt Q6NS38Inferred only

Reactions

10 reactions

a methylated nucleobase within DNA+2-oxoglutarate(2-)+dioxygena nucleobase within DNA+formaldehyde+succinate(2-)+carbon dioxide
Catalysed by ALKBH1 or ALKBH2 or ALKBH3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:30299CC BY 4.0Reference data
an N(3)-methyl-2'-deoxycytidine in single-stranded DNA+2-oxoglutarate(2-)+dioxygen

Other names

4 names

Resolves to: ALKBH2

Also called: ABH2Alkylated DNA repair protein alkB homolog 2Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2Oxy DC1

← Every protein Find it in the graph →