Proteins/UNIPROT:P18509

ADCYAP1

ProteinUNIPROT:P18509

PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus..

Function from UniProtKB (P18509), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

28 statements

28 statements · 4 reference databases · Subject: ADCYAP1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ADCYAP1 interacts with CPAMD8ProteinHetionet hetionet:interacts:116-27151Inferred only
ADCYAP1 interacts with DPP4ProteinHetionet hetionet:interacts:116-1803Inferred only
ADCYAP1 interacts with FAPProteinHetionet hetionet:interacts:116-2191Inferred only
ADCYAP1 interacts with SCTRProteinHetionet hetionet:interacts:116-6344Inferred only
ADCYAP1 participates in Activation of TRKA receptorsPathwayReactome R-HSA-187015Inferred only
ADCYAP1 participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
ADCYAP1 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
ADCYAP1 participates in Glucagon-type ligand receptorsPathwayReactome R-HSA-420092Inferred only
ADCYAP1 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
ADCYAP1 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
ADCYAP1 participates in NGF-independant TRKA activationPathwayReactome R-HSA-187024Inferred only
ADCYAP1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Show the remaining 16

ADCYAP1 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
ADCYAP1 participates in Signaling by NTRK1 (TRKA)PathwayReactome R-HSA-187037Inferred only
ADCYAP1 participates in Signaling by NTRKsPathwayReactome R-HSA-166520Inferred only
ADCYAP1 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
ADCYAP1 participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only
ADCYAP1 regulates positive regulation of cAMP/PKA signal transductionBiological processgene ontology P18509|GO:0141163Inferred only
ADCYAP1 regulates positive regulation of chemokine (C-C motif) ligand 5 productionBiological processgene ontology P18509|GO:0071651Inferred only
ADCYAP1 regulates positive regulation of cold-induced thermogenesisBiological processgene ontology P18509|GO:0120162Inferred only
ADCYAP1 regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology P18509|GO:0007204Inferred only
ADCYAP1 regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology P18509|GO:0070374Inferred only
ADCYAP1 regulates positive regulation of growth hormone secretionBiological processgene ontology P18509|GO:0060124Inferred only
ADCYAP1 regulates positive regulation of GTPase activityBiological processgene ontology P18509|GO:0043547Inferred only
ADCYAP1 regulates positive regulation of protein kinase activityBiological processgene ontology P18509|GO:0045860Inferred only
ADCYAP1 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P18509|GO:0045944Inferred only
ADCYAP1 regulates regulation of G protein-coupled receptor signaling pathwayBiological processgene ontology P18509|GO:0008277Inferred only
ADCYAP1 regulates regulation of protein localizationBiological processgene ontology P18509|GO:0032880Inferred only

Other names

7 names

Resolves to: ADCYAP1

Also called: ]PACAPPACAP-27PACAP-38PACAP27PACAP38PRP-48

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