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Proteins/UNIPROT:Q709F0
Participates in fatty acid beta-oxidation (FAO) and energy production in the central nervous system (CNS), and to a lesser extent in the liver. Catalyzes the first step in FAO, which consists in the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, with maximal activity towards saturated docosanoyl-CoA (CoA 22:0) in both the cerebellum and the liver. Among the different mitochondrial acyl-CoA dehydrogenases, its FAO activity overlaps with that of ACADV and ACADL, but plays a primary role in tissues where it is the main long-chain ACAD expressed, such as the CNS, where together with ACAD9, they accommodate the full spectrum of long chain fatty acid substrates..
Function from UniProtKB (Q709F0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
22 statements
22 statements · 8 reference databases · Subject: ACAD11 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
docosanoyl-CoA+FAD(2E)-docosenoyl-CoA+FADH2
Catalysed by ACADVL or ACADL or ACAD9 or ACAD11
Reaction pageLeft to rightBalancedEC 1.3.8.7, 1.3.8.8, 1.3.8.9, 1.3.99.-mitochondrial matrix
Human-GEM MAR03107CC BY 4.0Reference data
eicosanoyl-CoA+FAD(2E)-eicosenoyl-CoA+FADH2
Catalysed by
1 name
Resolves to: ACAD11
Reaction pageLeft to rightBalancedEC 1.3.8.7, 1.3.8.8, 1.3.8.9, 1.3.99.-mitochondrial matrix
Human-GEM MAR03111CC BY 4.0Reference data
CHEBI:83721+oxidized [electron-transfer flavoprotein]+hydronCHEBI:83727+reduced [electron-transfer flavoprotein]
Catalysed by ACADL or ACADVL or ACAD11 or ACAD9
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17721CC BY 4.0Reference data
docosanoyl-CoA+oxidized [electron-transfer flavoprotein]+hydron(2E)-docosenoyl-CoA+reduced [electron-transfer flavoprotein]
Catalysed by ACADL or ACADVL or ACAD11
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47228CC BY 4.0Reference data
tetracosanoyl-CoA+oxidized [electron-transfer flavoprotein]+hydron(2E)-tetracosenoyl-CoA+reduced [electron-transfer flavoprotein]
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47232CC BY 4.0Reference data
eicosanoyl-CoA+oxidized [electron-transfer flavoprotein]+hydron(2E)-eicosenoyl-CoA+reduced [electron-transfer flavoprotein]
Catalysed by ACADL or ACADVL or ACAD11 or ACAD9
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47236CC BY 4.0Reference data