leukoencephalopathy, diffuse hereditary, with spheroids 1

Findings

No curated finding names leukoencephalopathy, diffuse hereditary, with spheroids 1 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.

Definition

Onset and course

Middle age onset · Late young adult onset

HPO, annotations 2026-09-02

What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.

Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.

Where it sits

A kind of

• CSF1R-related disorder
• leukodystrophy
• leukoencephalopathy, hereditary diffuse, with spheroids

Resolves to: leukoencephalopathy, diffuse hereditary, with spheroids 1

Also called

Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented GliaALSPautosomal dominant leukoencephalopathy with neuroaxonal spheroidsCSF1R-related adult-onset leukoencephalopathy with axonal spheroids and pigmented gliaCSF1R-related ALSPdementia, familial, Neumann typefamilial dementia, Neumann typefamilial progressive subcortical gliosisFPSGgliosis, familial progressive subcorticalGPSCleukoencephalopathy with neuroaxonal spheroids, autosomal dominantleukoencephalopathy, adult-onset, with axonal spheroids and pigmented gliapigmentary orthochromatic leukodystrophy