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Proteins/UNIPROT:Q9HB15

KCNK12

Protein·UNIPROT:Q9HB15Potassium channel subfamily K member 12

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K(+) channel subunit that may homo- and heterodimerize to form functional channels with distinct regulatory and gating properties. Can heterodimerize with KCNK13 subunit to conduct K(+) outward rectifying currents at the plasma membrane. The homodimers are mainly retained in the endoplasmic reticulum compartment and may be targeted to the cell surface upon phosphorylation or other activation signals yet to be elucidated..

Function from UniProtKB (Q9HB15), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

7 statements

7 statements · 4 reference databases · Subject: KCNK12 · Sources: Bgee, Hetionet, Reactome, Rhea

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KCNK12 covaries with CEBPAProteinHetionet hetionet:covaries:1050-56660Inferred only
DIO3 covaries with KCNK12ProteinHetionet hetionet:covaries:1735-56660Inferred only
KCNK12 is expressed in olfactory bulbAnatomyBgee ENSG00000184261Inferred only
KCNK12 participates in Cardiac conductionPathwayReactome R-HSA-5576891Inferred only
KCNK12 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
KCNK12 participates in Phase 4 - resting membrane potentialPathwayReactome R-HSA-5576886Inferred only
K(+) is transported by KCNK12CompoundRhea RHEA:29463Inferred only

Reactions

1 reaction

K(+)K(+)
Transported by ANO9 or HTR3E or KCNU1 or KCNJ18 or TMEM150C or KCNK1 or KCNK3 or GRIN2D or KCNN4 or KCNQ3 or KCNQ2 or HCN1 and 136 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:29463CC BY 4.0Reference data

Other names

2 names

Resolves to: KCNK12

Also called: Tandem pore domain halothane-inhibited potassium channel 2THIK-2

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