Papers/PMID:23892310
Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.
Reproductive toxicology (Elmsford, N.Y.)2013The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
bisphenol A — decreases serum adiponectin
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Compared to negative controls, males in the BPA-5, BPA-50 and BPA-5000 groups had significantly lower serum adiponectin, with maximal reduction in the BPA-50 group.”
Quoted verbatim from Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.. - Study
- animal · not in humans
- Dose
- 5, 50 and 5000 ug/kg body weight/day to pregnant dams, GD 9 to 18
- Population
- Adult male CD-1 mice (19 weeks) exposed in utero via dams fed BPA once daily GD 9-18 in corn oil; dose strata BPA-5, BPA-50 and BPA-5000 ug/kg/day versus oil-only controls (the 500 and 50,000 ug/kg/day strata not significant); fed-state radioimmunoassay, 6-7 animals per group
Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation.2013PMID:23892310Permalink