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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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AnatomyTissues, by what is expressed there
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Catalyst

The evidence graph for human biochemistry. Every edge carries its source, its study design, and a grade computed from both.

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Papers/PMID:38218227

Efficacy and safety of collagen derivatives for osteoarthritis: A trial sequential meta-analysis.

Osteoarthritis and cartilage2024The record

1 finding drawn from this paper, on 1 compound across 1 endpoint.

Collagen

What it reported

How to read these marks

What moved

1 finding

Collagen — increases physical function (pooled across scales)
PreliminaryGrade D, Preliminary. Non-human or in vitro only.Finding
“Collagen derivatives exerted small-to-moderate effects on pain alleviation (standardized mean difference [SMD] -0.35, 95% confidence interval [CI] -0.48 to -0.22, moderate certainty) and function improvement (SMD -0.31, 95%CI -0.41 to -0.22, high certainty) compared with the control.”
Quoted verbatim from Efficacy and safety of collagen derivatives for osteoarthritis: A trial sequential meta-analysis..
Study

meta-analysis
Population

patients with osteoarthritis
Efficacy and safety of collagen derivatives for osteoarthritis: A trial sequential meta-analysis.2024PMID:38218227