Papers/PMID:41941966
Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.
Experimental gerontology2026The record
3 findings · 1 compound · 3 endpoints
What it reported
How to read these marksWhat moved
3 findings
creatine — decreases interleukin-6 concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Creatine provided additional benefits, increasing GPx, reducing IL-6/TNF-α and improving strength and function when combined with exercise modalities.”
Quoted verbatim from Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.. - Study
- RCT
- Duration
- 4 months
- Dose
- 3 g/day
- Population
- older adults (68.2±4.6y); creatine + resistance training (EB or AQ modalities pooled) vs placebo + training
Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.2026PMID:41941966Permalink
creatine — increases glutathione peroxidase activity
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Creatine provided additional benefits, increasing GPx, reducing IL-6/TNF-α and improving strength and function when combined with exercise modalities.”
Quoted verbatim from Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.. - Study
- RCT
- Duration
- 4 months
- Dose
- 3 g/day
- Population
- older adults (68.2±4.6y); creatine + resistance training (EB or AQ modalities pooled) vs placebo + training
Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.2026PMID:41941966Permalink
creatine — decreases tumour necrosis factor alpha concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Creatine provided additional benefits, increasing GPx, reducing IL-6/TNF-α and improving strength and function when combined with exercise modalities.”
Quoted verbatim from Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.. - Study
- RCT
- Duration
- 4 months
- Dose
- 3 g/day
- Population
- older adults (68.2±4.6y); creatine + resistance training (EB or AQ modalities pooled) vs placebo + training
Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.2026PMID:41941966Permalink