Papers/PMID:39205654
Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.
Gut microbes2024The record
3 findings · 1 compound · 3 endpoints
What it reported
How to read these marksWhat moved
3 findings
Lactobacillus acidophilus — decreases gamma-glutamyl transferase
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“After 14 days, UDCA+ L. acid group showed significantly lower AST (p < 0.05), ALT (p < 0.05), ALP, GGT (p < 0.05), and TBIL (p < 0.05) compared to UDCA, while no differences were found at the beginning of the trial (Supplemental Table 3).”
Quoted verbatim from Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.. - Study
- RCT
- Duration
- 14 days
- Dose
- 1 g fixed-dose tablet before each meal, three times a day, for 14 days, added to UDCA
- Population
- Adults with cholestatic liver disease; both arms received ursodeoxycholic acid 250 mg twice daily as background, the control arm UDCA alone; small single-centre trial
Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.2024PMID:39205654Permalink
Lactobacillus acidophilus — decreases alanine aminotransferase
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Compared with the sham group, serum ALT, AST, TBA, ALP, TBIL, and liver index were significantly increased in the BDL group, while L. acidophilus treatment significantly reduced (, Supplementary Figure 4a-c), which is consistently with Mdr2−/− mice (Supplementary Figure 5a-d).”
Quoted verbatim from Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.. - Study
- animal · not in humans
- Duration
- 9 days
- Dose
- live L. acidophilus 10^8 CFU in 200 microlitres per day by oral gavage for 9 days after bile duct ligation
- Population
- Male C57BL/6J mice with bile-duct-ligation cholestatic liver injury (n = 5 to 6 per group); L. acidophilus versus BDL without treatment
Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.2024PMID:39205654Permalink
Lactobacillus acidophilus — decreases aspartate aminotransferase
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Compared with the sham group, serum ALT, AST, TBA, ALP, TBIL, and liver index were significantly increased in the BDL group, while L. acidophilus treatment significantly reduced (, Supplementary Figure 4a-c), which is consistently with Mdr2−/− mice (Supplementary Figure 5a-d).”
Quoted verbatim from Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.. - Study
- animal · not in humans
- Duration
- 9 days
- Dose
- live L. acidophilus 10^8 CFU in 200 microlitres per day by oral gavage for 9 days after bile duct ligation
- Population
- Male C57BL/6J mice with bile-duct-ligation cholestatic liver injury (n = 5 to 6 per group); L. acidophilus versus BDL without treatment
Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.2024PMID:39205654Permalink