tetradecanedioyl-CoA

Three steps

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C14Dc->C12Dc), Peroxisomal
  2. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 3 moreperoxisomeOne of 3 routes

• hexadecanedioyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C14Dc->C12Dc), Peroxisomal
  2. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  3. Production of Hexadecanedioylcarnitine

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 4 moreperoxisome, cytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C14Dc->C12Dc), Peroxisomal
  2. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  3. fatty-acid-CoA ligase

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 2 moreperoxisome, cytosolOne of 2 routes

• undecanoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C14Dc->C12Dc), Peroxisomal
  2. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 7 moreperoxisome, cytosolOne of 3 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C14Dc->C12Dc), Peroxisomal
  2. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 9 moreperoxisome, cytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C14Dc->C12Dc), Peroxisomal
  2. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 5 moreperoxisome, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C14Dc->C12Dc), Peroxisomal
  2. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 4 moreperoxisome, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C14Dc->C12Dc), Peroxisomal
  2. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 9 moreperoxisome, cytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C14Dc->C12Dc), Peroxisomal
  2. Thioesterification of dodecanedioyl-CoA for Release into Cytosol
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 9 moreperoxisome, cytosolOne of 4 routes