hexadecanedioate

Three steps

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. Fatty Acid Activation (C16Dc), Endoplasmatic Reticulum
  2. Production of Hexadecanedioylcarnitine
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by ACSL5, CPT1A, CPT1C, CPT1Bendoplasmic reticulum, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. Fatty Acid Activation (C16Dc), Endoplasmatic Reticulum
  2. Production of Hexadecanedioylcarnitine
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by ACSL5, CPT1A, CPT1C, CPT1B and 7 moreendoplasmic reticulum, cytosolOne of 5 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. Fatty Acid Activation (C16Dc), Endoplasmatic Reticulum
  2. Production of Hexadecanedioylcarnitine
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by ACSL5, CPT1A, CPT1C, CPT1B and 2 moreendoplasmic reticulum, cytosol, peroxisomeOne of 3 routes

• pristanoyl-CoAReach from here →
  1. Fatty Acid Activation (C16Dc), Endoplasmatic Reticulum
  2. Production of Hexadecanedioylcarnitine
  3. fatty-acid-CoA ligase

  Catalysed by ACSL5, CPT1A, CPT1C, CPT1B and 1 moreendoplasmic reticulum, cytosolOne of 2 routes

• undecanoyl-CoAReach from here →
  1. Fatty Acid Activation (C16Dc), Endoplasmatic Reticulum
  2. Production of Hexadecanedioylcarnitine
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by ACSL5, CPT1A, CPT1C, CPT1B and 6 moreendoplasmic reticulum, cytosolOne of 3 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. Fatty Acid Activation (C16Dc), Endoplasmatic Reticulum
  2. Production of Hexadecanedioylcarnitine
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by ACSL5, CPT1A, CPT1C, CPT1B and 7 moreendoplasmic reticulum, cytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. Fatty Acid Activation (C16Dc), Endoplasmatic Reticulum
  2. Production of Hexadecanedioylcarnitine
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ACSL5, CPT1A, CPT1C, CPT1B and 4 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. Fatty Acid Activation (C16Dc), Endoplasmatic Reticulum
  2. Production of Hexadecanedioylcarnitine
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by ACSL5, CPT1A, CPT1C, CPT1B and 3 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. Fatty Acid Activation (C16Dc), Endoplasmatic Reticulum
  2. Production of Hexadecanedioylcarnitine
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by ACSL5, CPT1A, CPT1C, CPT1B and 7 moreendoplasmic reticulum, cytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. Fatty Acid Activation (C16Dc), Endoplasmatic Reticulum
  2. Production of Hexadecanedioylcarnitine
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by ACSL5, CPT1A, CPT1C, CPT1B and 7 moreendoplasmic reticulum, cytosolOne of 4 routes