pentanoate

Three steps

• 6alpha-hydroxyestroneReach from here →
  1. pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. estrone + reduced [NADPH--hemoprotein reductase] + O2 = 6alpha-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC22A9, STS, CYP1A1inner side of the membrane, outer side of the membrane, cytosol

• 15alpha-hydroxyestroneReach from here →
  1. pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)
  2. Estrone 3-sulfate sulfohydrolase
  3. estrone + reduced [NADPH--hemoprotein reductase] + O2 = 15alpha-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC22A9, STS, CYP1A1inner side of the membrane, outer side of the membrane, cytosol

• thromboxane B2Reach from here →
  1. pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A9, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• taurochenodeoxycholateReach from here →
  1. pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLC22A9, SLCO1B1, SLCO1A2, SLC7A9 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes