CHEBI:16523

Three steps

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by SLC3A2, SLC7A10, GSS, GPX1 and 3 moreextracellular space, cytosol

• taurochenodeoxycholateReach from here →
  1. transport of D-serine and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by SLC3A2, SLC7A10, GSS, SLCO1A2 and 2 moreextracellular space, cytosolOne of 3 routes