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glycine betaineFinding

Glycine betaine increases total cholesterol (TC)

raisesModerate evidenceFindingreplicated ×1

01 · The sentence it was drawn from

“Supplementation of 6 g/d of betaine for 6 wk increased total cholesterol concentrations by 0.42 mmol/l (8%) relative to placebo (see Table 3).”
Quoted verbatim from Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans.
This finding among the 116 findings on its endpoint

glycine betaine

Total cholesterol (TC)

raises

Effect as reported

0.42mean difference

Who
Healthy adults with higher plasma homocysteine, combined weighted effect of betaine 6 g/d versus placebo from two parallel and one crossover placebo-controlled double-blind trials
Dose studied
6 g/d of betaine (BUFA) dissolved in water, half after breakfast and half after the evening meal

Moderate evidencePMID 15916468 · 2005

02 · The study

Study
RCT
Duration
6 weeks

Evidence, by strength

  • strong
  • moderatethis finding
  • limited
  • very limited
  • insufficient

03 · The paper

PLoS medicine
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6ZTCTF9N30537V946D0R5ME