sodium hydrogencarbonate/Finding
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A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
No detected effect on all-cause mortality
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×1“Sodium bicarbonate therapy did not significantly reduce 90-day mortality compared to control (58.3% vs. 60.6%; risk ratio [RR], 0.96; 95%CI, 0.86-1.07; p = 0.51).”
Quoted verbatim from Sodium bicarbonate therapy in severe metabolic acidemia: an individual patient data meta-analysis of the BICAR-ICU and BICAR-ICU2 trials.. - Study
- meta-analysis
- Duration
- 3 months
- Dose
- intravenous sodium bicarbonate titrated to a pH >= 7.30
- Population
- Adults with severe metabolic acidemia (pH <= 7.20) in the BICAR-ICU and BICAR-ICU2 trials, individual patient data pooled; control arm received no sodium bicarbonate
Effect 0.96 risk ratio, 95% CI 0.86 to 1.07
Sodium bicarbonate therapy in severe metabolic acidemia: an individual patient data meta-analysis of the BICAR-ICU and BICAR-ICU2 trials.2026PMID:42472834Permalink
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- Every compound studied against All-cause mortality
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To cite this finding: https://catalystproject.ai/e/01M4PPT05NFYYWRG5CGQ3SDZR9