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Parkinson disease

MONDO:0005180Mondo

Findings

No curated finding names Parkinson disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.

A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

Definition from the Mondo Disease Ontology (MONDO:0005180), read 2026-09-29. CC BY 4.0.

Genes

11 genes

Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.

GBA1HGNC:4177
- Definitive · ClinGen · Autosomal dominant · 2022
- Definitive · Natera · Autosomal dominant · 2026
LRRK2HGNC:18618
- Definitive · ClinGen · Autosomal dominant · 2021
PARK7HGNC:16369
- Definitive · ClinGen · Autosomal recessive · 2022
PINK1HGNC:14581
- Definitive · ClinGen · Autosomal recessive · 2023
PRKNHGNC:8607
- Definitive · ClinGen · Autosomal recessive · 2023
SNCAHGNC:11138
- Definitive · Ambry Genetics · Autosomal dominant · 2025

Where it sits

A kind of: hereditary neurological disease
parkinsonian disorder
Narrower terms (6): late-onset Parkinson disease
Parkinson disease 16
Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development
Parkinson disease, mitochondrial
parkinsonian-pyramidal syndrome
young-onset Parkinson disease

Other names

3 names

Resolves to: Parkinson disease

Also called: paralysis agitansParkinson's diseasePD