late-onset Parkinson disease
MONDO:0008199Mondo
Findings
No curated finding names late-onset Parkinson disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A Parkinson disease that begins after around the age of 50.
Definition from the Mondo Disease Ontology (MONDO:0008199), read 2026-09-29. CC BY 4.0.
Features
34 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- ParkinsonismHPOHP:0001300
- Obligate (100% of cases)
- AkinesiaHPOHP:0002304
- Frequent (30% to 79% of cases)
- Chronic constipationHPOHP:0012450
- Frequent (30% to 79% of cases)
- DiplopiaHPOHP:0000651
- Frequent (30% to 79% of cases)
- DysphagiaHPOHP:0002015
- Frequent (30% to 79% of cases)
- Frequent fallsHPOHP:0002359
- Frequent (30% to 79% of cases)
- HyposmiaHPOHP:0004409
- Frequent (30% to 79% of cases)
- Parkinsonism with favorable response to dopaminergic medicationHPOHP:0002548
- Frequent (30% to 79% of cases)
- Resting tremorHPOHP:0002322
- Frequent (30% to 79% of cases)
- Spastic/hyperactive bladderHPOHP:0005340
- Frequent (30% to 79% of cases)
- AgitationHPOHP:0000713
- Occasional (5% to 29% of cases)
- ApathyHPOHP:0000741
- Occasional (5% to 29% of cases)
Show the remaining 22
- BradykinesiaHPOHP:0002067
- Occasional (5% to 29% of cases)
- Cerebral cortical atrophyHPOHP:0002120
- Occasional (5% to 29% of cases)
- DepressionHPOHP:0000716
- Occasional (5% to 29% of cases)
- DyskinesiaHPOHP:0100660
- Occasional (5% to 29% of cases)
- DystoniaHPOHP:0001332
- Occasional (5% to 29% of cases)
- GliosisHPOHP:0002171
- Occasional (5% to 29% of cases)
Genes
6 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- GBA1HGNC:4177
- Strong · Ambry Genetics · Autosomal dominant · 2024
- Strong · Genomics England PanelApp · Autosomal dominant · 2021
- Limited · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2020
- MAPTHGNC:6893
- Strong · Genomics England PanelApp · Autosomal dominant · 2021
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2020
- DNAJC13HGNC:30343
- Supportive · Orphanet · Autosomal dominant · 2021
- LRRK2HGNC:18618
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
- A kind of
Other names
10 names
Resolves to: late-onset Parkinson disease
- Also called
- autosomal dominant late-onset Parkinson diseasehereditary late onset Parkinson diseasehereditary late-onset Parkinson diseaseLOPDPARKParkinson disease, age of onset, modifier, MultifactorialParkinson disease, late-onsetParkinson disease, late-onset, susceptibility to, MultifactorialParkinson disease, susceptibility to, MultifactorialPD