TBC1D24

May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projection development, probably through negative modulation of ARF6 function. Required for the maintenance of postsynaptic neuron dendritic spines in the adult by suppressing ARF6 activity. Involved in the regulation of synaptic vesicle trafficking. Promotes axonal outgrowth and membrane trafficking at the growth cone (By similarity). Positively regulates radial migration and morphological maturation of pyramidal neurons during cortical development by preventing ARF6 activation (By similarity). In one study, has been shown to inhibit the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex. In another study, has been shown to positively regulate V-ATPase assembly in neurons which promotes acidification of lysosomes and synaptic vesicles (By similarity). This supports neuronal autophagy and also regulates synaptic vesicle reacidification and the maintenance of the synaptic vesicle reserve pool (By similarity). Protects neuronal cells against oxidative stress. Involved in the maintainenance of endosomal-mediated vesicle recycling and sustained exocytosis of hair cell ribbon synapses (By similarity). Facilitates formation of tubular recycling endosomes which promotes recycling of clathrin-independent endocytosis cargo proteins back to the plasma membrane..

Function from UniProtKB (Q9ULP9), read 2026-09-23. CC BY 4.0.