cataract
MONDO:0005129Mondo
Findings
No curated finding names cataract yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)
Definition from the Mondo Disease Ontology (MONDO:0005129), read 2026-09-29. CC BY 4.0.
Genes
11 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- CYP51A1HGNC:2649
- Definitive · G2P · Autosomal recessive · 2019
- FOXE3HGNC:3808
- Definitive · G2P · Autosomal recessive · 2018
- Definitive · G2P · Autosomal dominant · 2021
- VIMHGNC:12692
- Definitive · G2P · Autosomal dominant · 2017
- RRAGAHGNC:16963
- Strong · G2P · Autosomal dominant · 2017
- PGRMC1HGNC:16090
- Moderate · PanelApp Australia · X-linked · 2025
- HGNC:23437HGNC:23437
- Limited · G2P · Autosomal recessive · 2017
- Limited · PanelApp Australia · Autosomal recessive · 2025
- MFSD6LHGNC:26656
- Limited · G2P · Autosomal recessive · 2017
- PANK4HGNC:19366
- Limited · G2P · Autosomal dominant · 2019
- RNLSHGNC:25641
- Limited · G2P · Autosomal recessive · 2017
- TAPT1HGNC:26887
- Limited · G2P · Autosomal recessive · 2017
- WDR87HGNC:29934
- Limited · G2P · Autosomal recessive · 2017
Where it sits
- A kind of
- Narrower terms (29)
- autosomal dominant cataract
- bhaskar jagannathan syndrome
- cataract 1 multiple types
- cataract 12 multiple types
- cataract 18
- cataract 2, multiple types
- cataract 28
- cataract 29
- cataract 3 multiple types
- cataract 34 multiple types
- cataract 36
- cataract 4 multiple types
- cataract 48
- cataract 49
- cataract 50 with or without glaucoma
- cataract 9 multiple types
- cortical cataract
- craniostenosis cataract
- diabetes mellitus type 2 associated cataract
- diabetic cataract
- early-onset non-syndromic cataract
- hypermature cataract
- immature cataract
Other names
2 names
Resolves to: cataract
- Also called
- cataract (disease)opacity of the lens