atypical progressive supranuclear palsy syndrome
Findings
No curated finding names atypical progressive supranuclear palsy syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Atypical progressive supranuclear palsy (atypical PSP) is a group of clinical syndromes associated with underlying PSP-tau pathology, that do not conform to the classic presentation of PSP (Richardson syndrome), a rare late-onset neurodegenerative disease. The group comprises PSP-Parkinsonism (PSP-P), PSP-Pure akinesia with gait freezing (PSP-PAGF), PSP-corticobasal syndrome (PSP-CBS) and PSP-progressive non fluent aphasia (PSP-PNFA).
Definition from the Mondo Disease Ontology (MONDO:0020488), read 2026-09-29. CC BY 4.0.
Features
28 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- ParkinsonismHPOHP:0001300
- Obligate (100% of cases)
- Abnormality of eye movementHPOHP:0000496
- Frequent (30% to 79% of cases)
- BlepharospasmHPOHP:0000643
- Frequent (30% to 79% of cases)
- BradykinesiaHPOHP:0002067
- Frequent (30% to 79% of cases)
- DementiaHPOHP:0000726
- Frequent (30% to 79% of cases)
- Downgaze palsyHPOHP:0025330
- Frequent (30% to 79% of cases)
- DysgraphiaHPO
Show the remaining 16
- Mental deteriorationHPOHP:0001268
- Frequent (30% to 79% of cases)
- Oculomotor apraxiaHPOHP:0000657
- Frequent (30% to 79% of cases)
- OphthalmoparesisHPOHP:0000597
- Frequent (30% to 79% of cases)
- RigidityHPOHP:0002063
- Frequent (30% to 79% of cases)
- Speech apraxiaHPOHP:0011098
- Frequent (30% to 79% of cases)
- Speech articulation difficultiesHPOHP:0009088
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: atypical progressive supranuclear palsy syndrome
- Also called
- atypical PSP syndrome