progressive supranuclear palsy
MONDO:0019037Mondo
Findings
No curated finding names progressive supranuclear palsy yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare late-onset neurodegenerative disease characterized by supranuclear gaze palsy, postural instability, progressive rigidity, and mild dementia.
Definition from the Mondo Disease Ontology (MONDO:0019037), read 2026-09-29. CC BY 4.0.
Features
33 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal synaptic transmissionHPOHP:0012535
- Very frequent (80% to 99% of cases)
- DysphagiaHPOHP:0002015
- Very frequent (80% to 99% of cases)
- FallsHPOHP:0002527
- Very frequent (80% to 99% of cases)
- ImpulsivityHPOHP:0100710
- Very frequent (80% to 99% of cases)
- Neuronal loss in central nervous systemHPOHP:0002529
- Very frequent (80% to 99% of cases)
- Postural instabilityHPOHP:0002172
- Very frequent (80% to 99% of cases)
- Supranuclear gaze palsyHPOHP:0000605
- Very frequent (80% to 99% of cases)
- Supranuclear ophthalmoplegiaHPOHP:0000623
- Very frequent (80% to 99% of cases)
- Unsteady gaitHPOHP:0002317
- Very frequent (80% to 99% of cases)
- ApathyHPOHP:0000741
- Frequent (30% to 79% of cases)
- AphasiaHPOHP:0002381
- Frequent (30% to 79% of cases)
- BlepharospasmHPOHP:0000643
- Frequent (30% to 79% of cases)
Show the remaining 21
- BradykinesiaHPOHP:0002067
- Frequent (30% to 79% of cases)
- Cerebral cortical atrophyHPOHP:0002120
- Frequent (30% to 79% of cases)
- Cognitive impairmentHPOHP:0100543
- Frequent (30% to 79% of cases)
- Delayed speech and language developmentHPOHP:0000750
- Frequent (30% to 79% of cases)
- DepressionHPOHP:0000716
- Frequent (30% to 79% of cases)
- DysarthriaHPOHP:0001260
- Frequent (30% to 79% of cases)
Where it sits
Other names
4 names
Resolves to: progressive supranuclear palsy
- Also called
- progressive supranuclear ophthalmoplegiaPSP syndromeSteele-Richardson-Olszewski diseaseSteele-Richardson-Olszewski syndrome