progressive supranuclear palsy-corticobasal syndrome
MONDO:0016563Mondo
Findings
No curated finding names progressive supranuclear palsy-corticobasal syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
PSP-corticobasal syndrome (PSP-CBS) is an atypical variant of progressive supranuclear palsy (PSP), a rare late-onset neurodegenerative disease.
Definition from the Mondo Disease Ontology (MONDO:0016563), read 2026-09-29. CC BY 4.0.
Features
29 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- BradykinesiaHPOHP:0002067
- Obligate (100% of cases)
- Abnormal pyramidal signHPOHP:0007256
- Very frequent (80% to 99% of cases)
- ApraxiaHPOHP:0002186
- Very frequent (80% to 99% of cases)
- Focal dystoniaHPOHP:0004373
- Very frequent (80% to 99% of cases)
- Limb apraxiaHPOHP:0030217
- Very frequent (80% to 99% of cases)
- Postural instabilityHPOHP:0002172
- Very frequent (80% to 99% of cases)
- Slow saccadic eye movementsHPOHP:0000514
- Very frequent (80% to 99% of cases)
- Abnormal saccadic eye movementsHPOHP:0000570
- Frequent (30% to 79% of cases)
- AphasiaHPOHP:0002381
- Frequent (30% to 79% of cases)
- Diminished movementHPOHP:0002374
- Frequent (30% to 79% of cases)
- DysarthriaHPOHP:0001260
- Frequent (30% to 79% of cases)
- Frequent fallsHPOHP:0002359
- Frequent (30% to 79% of cases)
Reported absent (1)
- Frontal release signsHPOHP:0000743
Show the remaining 17
- Hand clenchingHPOHP:0001188
- Frequent (30% to 79% of cases)
- Involuntary movementsHPOHP:0004305
- Frequent (30% to 79% of cases)
- Limb myoclonusHPOHP:0045084
- Frequent (30% to 79% of cases)
- Memory impairmentHPOHP:0002354
- Frequent (30% to 79% of cases)
- Mental deteriorationHPOHP:0001268
- Frequent (30% to 79% of cases)
- Progressive extrapyramidal muscular rigidityHPOHP:0007158
- Frequent (30% to 79% of cases)
Where it sits
Other names
2 names
Resolves to: progressive supranuclear palsy-corticobasal syndrome
- Also called
- PSP-CBSPSP-corticobasal syndrome