progressive supranuclear palsy-pure akinesia with gait freezing syndrome
MONDO:0016562Mondo
Findings
No curated finding names progressive supranuclear palsy-pure akinesia with gait freezing syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
PSP-Pure akinesia with gait freezing (PSP-PAGF) is an atypical variant of progressive supranuclear palsy (PSP), a rare late-onset neurodegenerative disease.
Definition from the Mondo Disease Ontology (MONDO:0016562), read 2026-09-29. CC BY 4.0.
Features
19 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AkinesiaHPOHP:0002304
- Obligate (100% of cases)
- Freezing of gaitHPOHP:0031825
- Obligate (100% of cases)
- Unsteady gaitHPOHP:0002317
- Very frequent (80% to 99% of cases)
- Abnormal prosodyHPOHP:0031434
- Frequent (30% to 79% of cases)
- Fixed facial expressionHPOHP:0005329
- Frequent (30% to 79% of cases)
- Gait imbalanceHPOHP:0002141
- Frequent (30% to 79% of cases)
- MicrographiaHPOHP:0031908
- Frequent (30% to 79% of cases)
- PalilaliaHPOHP:0031814
- Frequent (30% to 79% of cases)
- Spastic dysarthriaHPOHP:0002464
- Frequent (30% to 79% of cases)
- TachylaliaHPOHP:0031937
- Frequent (30% to 79% of cases)
- Weak voiceHPOHP:0001621
- Frequent (30% to 79% of cases)
- DementiaHPOHP:0000726
- Occasional (5% to 29% of cases)
Reported absent (2)
- BradykinesiaHPOHP:0002067
- RigidityHPOHP:0002063
Show the remaining 7
- Distal lower limb muscle weaknessHPOHP:0009053
- Occasional (5% to 29% of cases)
- FallsHPOHP:0002527
- Occasional (5% to 29% of cases)
- Loss of ambulationHPOHP:0002505
- Occasional (5% to 29% of cases)
- Short stepped shuffling gaitHPOHP:0007311
- Occasional (5% to 29% of cases)
- BlepharospasmHPOHP:0000643
- Very rare (1% to 4% of cases)
- Hypometric saccadesHPOHP:0000571
- Very rare (1% to 4% of cases)
Where it sits
Other names
2 names
Resolves to: progressive supranuclear palsy-pure akinesia with gait freezing syndrome
- Also called
- PSP-PAGFPSP-pure akinesia with gait freezing