Papers/PMID:42656268
Integrated meta-analysis and exploratory small-sample machine learning to evaluate curcumin against osteoporosis: a preclinical evidence-based study.
Frontiers in endocrinology2026The record
4 findings drawn from this paper, on 1 compound across 4 endpoints, 1 of them null.
What it reported
How to read these marksWhat moved
3 findings
curcumin — decreases malondialdehyde (circulating)
PreliminaryGrade D, Preliminary. Non-human or in vitro only.Findingreplicated ×4“Furthermore, synthesized data from three studies indicated that curcumin was associated with reduced levels of MDA, a marker of lipid peroxidation (MD = -1.99, 95% CI = -3.22 to -0.77, p = 0.001;.”
Quoted verbatim from Integrated meta-analysis and exploratory small-sample machine learning to evaluate curcumin against osteoporosis: a preclinical evidence-based study.. - Study
- animal · not in humans
- Population
- ovariectomized/GIOP/metabolic osteoporosis rodent models, meta-analysis of 3 studies
Effect -1.99 mean difference, 95% CI -3.22 to -0.77
Integrated meta-analysis and exploratory small-sample machine learning to evaluate curcumin against osteoporosis: a preclinical evidence-based study.2026PMID:42656268
curcumin — decreases interleukin-6 concentration
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Findingreplicated ×3“Regarding pro-inflammatory cytokines, the results from four studies showed that curcumin treatment led to a significant reduction in IL-6 concentrations (SMD = -2.59, 95% CI = -4.32 to -0.86, p = 0.003).”
Quoted verbatim from Integrated meta-analysis and exploratory small-sample machine learning to evaluate curcumin against osteoporosis: a preclinical evidence-based study.. - Study
- animal · not in humans
- Population
- ovariectomized/GIOP/metabolic osteoporosis rodent models, meta-analysis of 4 studies
Effect -2.59 standardised mean difference, 95% CI -4.32 to -0.86
Integrated meta-analysis and exploratory small-sample machine learning to evaluate curcumin against osteoporosis: a preclinical evidence-based study.2026PMID:42656268
curcumin — decreases tumour necrosis factor alpha concentration
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Findingreplicated ×1“Furthermore, a meta-analysis of three studies suggested that curcumin significantly suppressed TNF-α levels (MD = -71.01, 95% CI = -98.65 to -43.37, p < 0.001).”
Quoted verbatim from Integrated meta-analysis and exploratory small-sample machine learning to evaluate curcumin against osteoporosis: a preclinical evidence-based study.. - Study
- animal · not in humans
- Population
- ovariectomized/GIOP/metabolic osteoporosis rodent models, meta-analysis of 3 studies
Effect -71.01 mean difference, 95% CI -98.65 to -43.37
Integrated meta-analysis and exploratory small-sample machine learning to evaluate curcumin against osteoporosis: a preclinical evidence-based study.2026PMID:42656268
What did not
1 finding
curcumin — no detected effect on serum alkaline phosphatase
PreliminaryGrade D, Preliminary. Non-human or in vitro only.FindingNull resultreplicated ×3“Concerning bone formation and mineral metabolism, pooled estimates from seven studies revealed that curcumin did not significantly alter ALP levels (SMD = -1.00, 95% CI = -3.14 to 1.13, p = 0.36).”
Quoted verbatim from Integrated meta-analysis and exploratory small-sample machine learning to evaluate curcumin against osteoporosis: a preclinical evidence-based study.. - Study
- animal · not in humans
- Population
- ovariectomized/GIOP/metabolic osteoporosis rodent models, meta-analysis of 7 studies
Effect -1 standardised mean difference, 95% CI -3.14 to 1.13
Integrated meta-analysis and exploratory small-sample machine learning to evaluate curcumin against osteoporosis: a preclinical evidence-based study.2026PMID:42656268