Papers/PMID:42487213
Comparative Efficacy and Safety of Tirzepatide in Asian and Non-Asian Adults With Obesity Without Diabetes: A Systematic Review and Meta-Analysis.
Endocrinology, diabetes & metabolism2026The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
tirzepatide — decreases body mass index
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“Tirzepatide 15 mg/MTD produced greater reductions in BMI (MD −7.21 kg/m2; 95% CI −8.79 to −5.63; p < 0.00001; I 2 = 96%) and waist circumference (MD −14.27 cm; 95% CI −15.43 to −13.10; p < 0.00001; I 2 = 23%) versus placebo.”
Quoted verbatim from Comparative Efficacy and Safety of Tirzepatide in Asian and Non-Asian Adults With Obesity Without Diabetes: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Dose
- 15 mg or maximum tolerated dose, once weekly
- Population
- Adults with obesity or overweight without diabetes, pooled across SURMOUNT placebo-controlled trials
Effect -7.21 mean difference, 95% CI -8.79 to -5.63
Comparative Efficacy and Safety of Tirzepatide in Asian and Non-Asian Adults With Obesity Without Diabetes: A Systematic Review and Meta-Analysis.2026PMID:42487213Permalink
tirzepatide — decreases body mass
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×2“Tirzepatide 15 mg/MTD produced an 18.04% greater reduction in body weight versus placebo (95% CI −19.86 to −16.22; p < 0.00001; I 2 = 77%).”
Quoted verbatim from Comparative Efficacy and Safety of Tirzepatide in Asian and Non-Asian Adults With Obesity Without Diabetes: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Dose
- 15 mg or maximum tolerated dose, once weekly
- Population
- Adults with obesity or overweight without diabetes, pooled across five phase 3 SURMOUNT placebo-controlled trials (six comparisons, N = 4022); percentage change in body weight
Comparative Efficacy and Safety of Tirzepatide in Asian and Non-Asian Adults With Obesity Without Diabetes: A Systematic Review and Meta-Analysis.2026PMID:42487213Permalink